Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients
Identifieur interne : 002725 ( Main/Exploration ); précédent : 002724; suivant : 002726Oculomotor function in multiple system atrophy: Clinical and laboratory features in 30 patients
Auteurs : Tim Anderson [Nouvelle-Zélande] ; Linda Luxon [Royaume-Uni] ; Niall Quinn [Royaume-Uni] ; Susan Daniel [Royaume-Uni] ; C. David Marsden [Nouvelle-Zélande] ; Adolfo Bronstein [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Anatomic pathology, Apraxias (diagnosis), Apraxias (epidemiology), Caloric Tests, Diagnosis, Differential, Electrooculography, Female, Fixation, Ocular (physiology), Human, Humans, Male, Middle Aged, Multiple System Atrophy (diagnosis), Multiple System Atrophy (epidemiology), Multiple System Atrophy (pathology), Multiple system atrophy, Nervous system diseases, Nystagmus, Nystagmus, Physiologic (physiology), Oculomotor Nerve Diseases (epidemiology), Oculomotor Nerve Diseases (physiopathology), Parkinson Disease (diagnosis), Positioning, Reflex, Vestibulo-Ocular (physiology), Saccades (physiology), Severity of Illness Index, Vestibular Diseases (epidemiology), Vestibular Diseases (physiopathology), multiple system atrophy (MSA), oculomotor, pathology, positioning downbeat nystagmus (pDBN), saccades, vestibular.
- MESH :
- diagnosis : Apraxias, Multiple System Atrophy, Parkinson Disease.
- epidemiology : Apraxias, Multiple System Atrophy, Oculomotor Nerve Diseases, Vestibular Diseases.
- pathology : Multiple System Atrophy.
- physiology : Fixation, Ocular, Nystagmus, Physiologic, Reflex, Vestibulo-Ocular, Saccades.
- physiopathology : Oculomotor Nerve Diseases, Vestibular Diseases.
- Caloric Tests, Diagnosis, Differential, Electrooculography, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
We reviewed the clinical and laboratory oculomotor features in 30 patients with probable multiple system atrophy (MSA), 22 with MSA‐P and 8 with MSA‐C. Six patients were also examined post mortem, MSA being confirmed in four and excluded in two (Parkinson's disease and progressive supranuclear palsy). Clinical examination showed the following abnormalities; excessive square wave jerks—21 of 30 patients; mild vertical supranuclear gaze palsy—8 of 30; gaze‐evoked nystagmus—12 of 30 patients, three of whom had no extraocular evidence of cerebellar dysfunction; positioning downbeat nystagmus—10 of 25; mild or moderate saccadic hypometria—22 of 30; impaired (“broken up”) smooth pursuit—28 of 30; reduced VOR suppression—16 of 24. Electro‐oculography and caloric testing did not add significant extra information. In patients presenting with an akinetic‐rigid syndrome it can be difficult to differentiate idiopathic Parkinson's disease from MSA‐P and other causes of atypical parkinsonism. Our findings suggest that the presence of excessive square wave jerks, mild – moderate hypometria of saccades, impaired VOR suppression, spontaneous nystagmus or positioning downbeat nystagmus may be oculomotor “red flags” or clues to the presence of MSA. Further, the presence of clinically slow saccades, or moderate‐to‐severe gaze restriction, suggests a diagnosis other than MSA. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21999
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-05-15">2008-05-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="977">977</biblScope><biblScope unit="page" to="984">984</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3D3FD14B982659679FAD68B5BA492EEFE0F0F699</idno><idno type="DOI">10.1002/mds.21999</idno><idno type="ArticleID">MDS21999</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Apraxias (diagnosis)</term><term>Apraxias (epidemiology)</term><term>Caloric Tests</term><term>Diagnosis, Differential</term><term>Electrooculography</term><term>Female</term><term>Fixation, Ocular (physiology)</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (diagnosis)</term><term>Multiple System Atrophy (epidemiology)</term><term>Multiple System Atrophy (pathology)</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Nystagmus</term><term>Nystagmus, Physiologic (physiology)</term><term>Oculomotor Nerve Diseases (epidemiology)</term><term>Oculomotor Nerve Diseases (physiopathology)</term><term>Parkinson Disease (diagnosis)</term><term>Positioning</term><term>Reflex, Vestibulo-Ocular (physiology)</term><term>Saccades (physiology)</term><term>Severity of Illness Index</term><term>Vestibular Diseases (epidemiology)</term><term>Vestibular Diseases (physiopathology)</term><term>multiple system atrophy (MSA)</term><term>oculomotor</term><term>pathology</term><term>positioning downbeat nystagmus (pDBN)</term><term>saccades</term><term>vestibular</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Apraxias</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Apraxias</term><term>Multiple System Atrophy</term><term>Oculomotor Nerve Diseases</term><term>Vestibular Diseases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple System Atrophy</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Fixation, Ocular</term><term>Nystagmus, Physiologic</term><term>Reflex, Vestibulo-Ocular</term><term>Saccades</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Oculomotor Nerve Diseases</term><term>Vestibular Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Caloric Tests</term><term>Diagnosis, Differential</term><term>Electrooculography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anatomopathologie</term><term>Atrophie multisystématisée</term><term>Homme</term><term>Nystagmus</term><term>Pathologie du système nerveux</term><term>Positionnement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We reviewed the clinical and laboratory oculomotor features in 30 patients with probable multiple system atrophy (MSA), 22 with MSA‐P and 8 with MSA‐C. Six patients were also examined post mortem, MSA being confirmed in four and excluded in two (Parkinson's disease and progressive supranuclear palsy). Clinical examination showed the following abnormalities; excessive square wave jerks—21 of 30 patients; mild vertical supranuclear gaze palsy—8 of 30; gaze‐evoked nystagmus—12 of 30 patients, three of whom had no extraocular evidence of cerebellar dysfunction; positioning downbeat nystagmus—10 of 25; mild or moderate saccadic hypometria—22 of 30; impaired (“broken up”) smooth pursuit—28 of 30; reduced VOR suppression—16 of 24. Electro‐oculography and caloric testing did not add significant extra information. In patients presenting with an akinetic‐rigid syndrome it can be difficult to differentiate idiopathic Parkinson's disease from MSA‐P and other causes of atypical parkinsonism. Our findings suggest that the presence of excessive square wave jerks, mild – moderate hypometria of saccades, impaired VOR suppression, spontaneous nystagmus or positioning downbeat nystagmus may be oculomotor “red flags” or clues to the presence of MSA. Further, the presence of clinically slow saccades, or moderate‐to‐severe gaze restriction, suggests a diagnosis other than MSA. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Nouvelle-Zélande</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Anderson, Tim" sort="Anderson, Tim" uniqKey="Anderson T" first="Tim" last="Anderson">Tim Anderson</name></noRegion><name sortKey="David Marsden, C" sort="David Marsden, C" uniqKey="David Marsden C" first="C." last="David Marsden">C. David Marsden</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Luxon, Linda" sort="Luxon, Linda" uniqKey="Luxon L" first="Linda" last="Luxon">Linda Luxon</name></region><name sortKey="Bronstein, Adolfo" sort="Bronstein, Adolfo" uniqKey="Bronstein A" first="Adolfo" last="Bronstein">Adolfo Bronstein</name><name sortKey="Bronstein, Adolfo" sort="Bronstein, Adolfo" uniqKey="Bronstein A" first="Adolfo" last="Bronstein">Adolfo Bronstein</name><name sortKey="Daniel, Susan" sort="Daniel, Susan" uniqKey="Daniel S" first="Susan" last="Daniel">Susan Daniel</name><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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